核心技术
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微芯发表论文:

  • Li PP, Shan S, Chen YT, Ning ZQ, Sun SJ, Liu Q, Lu XP, Xie MZ, Shen ZF. The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol. Jul 2006; 148(5): 610-618.
  • Deng T, Shan S, Li PP, Shen ZF, Lu XP, Cheng J, Ning ZQ. Peroxisome proliferator-activated receptor-g transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1. Endocrinology. 2006.147 (2): 875-884. (SCI)
  • Deng T, Shan S, Li ZB, Wu ZW, Liao CZ, Ko CB, Lu XP, Cheng J, Ning ZQ. A new retinoid-like compound that activates peroxisome proliferator-activated receptors and lowers blood glucose in diabetic mice. Biological & Pharmaceutical Bulletin. 2005.
  • Liu L, Ning ZQ, Shan S, Zhang K, Deng T, Lu XP, Cheng YY. Phthalide Lactones from Ligusticum chuanxiong Inhibit Lipopolysaccharide-Induced TNF-α Production and TNF-α-Mediated NF-κB Activation. 2005. (71):808-813
  • Liao CZ, Liu B, Shi LM, Zhou JJ, Lu XP. Construction of a Virtual Combinatorial Library Using SMILES Strings to Discover Potential Structure-Diverse PPAR Modulators. European Journal of Medicinal Chemistry. 2005 (40/7): 632-640.(SCI)
  • Xie AH, Li BY, Liao CZ, Li ZB, Lu XP, Shi LM, Zhou JJ. Docking study of HDAC: Implication for Benzamide inhibitors binding mode. Acta Phys. –Chim. Sin. (Wuli Huaxue Xuebao). 2004. 20 (6):569-572.
  • Shi LM, Tong WD, Lu XP. Biochemoinformatics: Integrating Bioinformatics and Chemoinformatics for Drug Discovery and Development. European BioPharmaceutical Review. Autumn (Sept/Oct) 2003:59-62.
  • Shi LM. DNA chip technology: more interesting applications to open up in Life Sciences, in “50 Years of DNA”, pp.57-59, April 2003. ISBN 0-9545135-0-9. (A Business Weekly publication in association with The Wellcome Trust, Cambridge, U.K.; Foreword by U.K. Prime Minister Tony Blair). Invited review.
  • Shi LM, Hu WM, Su ZQ, Lu XP, Tong WD. Chapter 13: Microarrays: technologies and applications. in Fungal Genomics, Volume 3 of Applied Mycology and Biotechnology, D. K. Arora and G. G. Khachatourians (Editors). Elsevier Science. 2003. 271-293. IS
  • 兰玉坤, 马保顺, 尹子卉, 廖晨钟, 山松, 李志良, 宁志强, 鲁先平, 李志斌. 新型胰岛素增敏剂西格列羧的合成. 中国新药杂志. 2004.13 (8):718-720.
  • 廖晨钟, 石乐明, 周家驹, 鲁先平. 一种用SMILES码构建虚拟组合化学库的新方法.计算机与应用化学. 2005. 22 (4):247-252.
  • 谢爱华,李伯玉,山松, 邓沱,李志斌,宁志强,胡伟明,石乐明,周家驹,鲁先平. 以组蛋白去乙酰化酶为靶标的抗癌药物研发进展. 中国新药杂志. 2005.14 (1):010-015
  • 马保顺, 兰玉坤, 吴仲闻, 尹子卉, 鲁先平, 李志斌. 5-[[4-[2-(5,6,7,8-四氢-5,5,8,8-四甲基)萘氧-2-基]乙氧基]苄基]-2,4-噻唑烷二酮的合成. 合成化学. 2004. 12 (5):481-483.
  • 苏振强,鲁先平,石乐明. 分布式多线程并行处理技术在大规模化学结构检索数据库系统中的应用. 计算机与应用化学. 2004. 21 (5):659-664
  • Liao CZ, Xie AH, Shi LM, Zhou JJ, Lu XP. Eigenvalue Analysis of Peroxisome Proliferator-Activated Receptor γ Agonists. J. Chem. Info. Comput. Sc. 2004. 44:230-238.(SCI)
  • 尹子卉,吴仲闻,兰玉坤,廖晨钟,山松,李志良,宁志强,鲁先平,李志斌. 新型抗肿瘤组蛋白去乙酰化酶抑制剂西达本胺的合成. 中国新药杂志. 2004.13 (6):536-538
  • Shi LM, Tong WD. Data mining: an integrated approach for drug discovery. in Biochips: Technology and Applications. W.L Xing and J. Cheng (Editors). Berlin, Springer. July 2003. 71-89. ISBN 3-540-00423-8. Invited book chapter.
  • Shi LM, Su ZQ, Xie AH, Liao CZ, Qiao W, Zhang DJ, Shan S, Pan DS, Li ZB, Ning ZQ, Hu WM, Lu XP. An integrated biochemoinformatics system for drug discovery: managing and mining chemical structure information, biological activity fingerprints, and gene expression profiling patterns.
  • Li ZB, Liao CZ, Ko CB, Shan S, Tong HY, Yin ZH, Pan DS, Wong KW, Shi LM, Ning ZQ, Hu WM, Zhou JJ, Chung SM, Lu XP. Design, Synthesis and Evaluation of Novel Noncyclic 1,3-Dicarbonyl Compounds as PPARα Selective Activators. Bioorganic and Medicin
  • Xie AH, Liao CZ, Li ZB, Ning ZQ, Hu WM, Xianping Lu, Shi LM, Zhou JJ. Quantitative Structure-activity Relationship Study of Histone Deacetylase Iinhibitors. Current Medicinal Chemistry Anti-Cancer Agents. 2004 May. 4(3):273-99
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  • Liao CZ, Xie AH, Zhou JJ, Shi LM, Li ZB, Lu XP. 3D QSAR Studies on Peroxisome Proliferator-activated receptor agonists using CoMFA and CoMSIA. J. Mol. Model. 2004. 10:165-177.(SCI)
  • 苏振强,潘德思,山松,胡伟明,宁志强,李志斌,石乐明,廖晨钟,张大杰,乔伟,鲁先平. 生化信息学在药物创新过程中的重要作用. 中国新药杂志. 2004. 13 (5):385-388
  • Xie AH, Liao CZ, Li ZB, Ning ZQ, Hu WM, Lu XP, Shi LM, Zhou JJ. Quantitative Structure-activity Relationship Study of Bisphosphonates. Internet Electronic Journal of Molecular Design.2003. 2000-000.
  • 廖晨钟, 邓沱, 山松, 潘德思, 李志斌, 宁志强, 胡伟明, 石乐明, 周家驹, 鲁先平. 以PPAR为靶标的抗2型糖尿病药物研发策略.中国新药杂志. 2003.12 (12): 980-983.
  • Lu XP, Li ZB, Ning ZQ, Shi LM, and Hu WM. Application of Chemical Genomics Approach in Identifying Novel PPAR Agonists with in vivo Anti-Diabetic and Lipid-Modulating Activities. Preclinica. Sept/Oct 2003. 4: 210.
  • 苏振强,廖晨钟,谢爱华,鲁先平,石乐明. 基于甲骨文数据库管理系统的化学结构检索数据库的设计与实现. 计算机与应用化学. 2003. 20 (5):556-562.
  • Shi LM, Hu WM, Su ZQ, Lu XP, Tong WD. Chapter 13: Microarrays: technologies and applications. in Fungal Genomics, Volume 3 of Applied Mycology and Biotechnology, D. K. Arora and G. G. Khachatourians (Editors). Elsevier Science. 2003. 271-293. IS
  • Shi LM. Arrays, molecular diagnostics, personalized therapy, and informatics. Expert Review of Molecular Diagnostics.2001.1 (4):363-365. Invited editorial.





部分客户及合作者发表论文:

  1. 董梅,邢镨元,石远凯,冯奉仪 西达本胺在晚期恶性肿瘤患者中的I期临床耐受性研究 中国新药杂志 2009, 18 1745-1750.

  2. 陈佳1,周武庆1,陈浩1,宋亚丽1,2,蔡丽敏1,3,辛崇美1,曾学思1,孙建方1,西达本胺对恶性黑素瘤细胞系A375的体外抗增殖作用, 中华皮肤科杂志 2009, 42(4) 255-258.

  3. Huang ZX, Tian HY, Hu ZF, Zhou YB, Zhao J, Yao KT.  GenCLiP: a software program for clustering gene lists by literature profiling and constructing gene co-occurrence networks related to custom keywords.  BMC Bioinformatics. 2008 Jul 13; 9:308.

  4. Fang W, Li X, Jiang Q, Liu Z, Yang H, Wang S, Xie S, Liu Q, Liu T, Huang J, Xie W, Li Z, Zhao Y, Wang E, Marincola FM, Yao K. Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China. J Transl Med. 2008 Jun 20; 6:32.

  5. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E. let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells. Cell. 2007 Dec 14; 131(6):1109-23.

  6. Zhao ZW, Bi YY, Xia Y, Tao N, Ma Q. Differential expression of cytochrome P450 genes associated with benzene-induced hematotoxicity. The FASEB Journal. 2007. 21:886.

  7. Zhang Y, He X, Chen X, Ma H, Liu D, Luo J, Du Z, Jin Y, Xiong Y, He J, Fang D, Wang K, Lawson WE, Hui JC, Zheng Z, Wu G. Enhanced external counterpulsation inhibits intimal hyperplasia by modifying shear stress responsive gene expression in hypercholesterolemic pigs. Circulation. 2007 Jul 31; 116(5):526-34.